Serena graduated from the University of Hull (UK) with an LLB (Honours) in 1995. She was called to the Singapore Bar on 31st May 1999.

Since graduation,Serena practised at M/s Cheong Hoe & Partners and M/s Haridass Ho & Partners respectively. She joined M/s Yeo Leong & Peh LLC in 2003 as a Legal Associate in the banking litigation department. Apart from banking litigation, her other areas of practice include contractual breach and claims, motor accident and personal injury claims, probate, matrimonial matters, shipping and marine law.